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Lynn Y Sakai Selected Research

Aneurysm (Aneurysms)

11/2023Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models.
4/2022A Novel Model of Tobacco Smoke-Mediated Aortic Injury.
1/2022Circulating fibrillin fragment concentrations in patients with and without aortic pathology.
10/2013Thoracic aortic aneurysm frequency and dissection are associated with fibrillin-1 fragment concentrations in circulation.
3/2006Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

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Lynn Y Sakai Research Topics

Disease

10Marfan Syndrome (Marfan's Syndrome)
01/2020 - 12/2002
5Aneurysm (Aneurysms)
11/2023 - 03/2006
3Inborn Genetic Diseases (Disease, Hereditary)
01/2019 - 06/2010
3Weill-Marchesani Syndrome
09/2015 - 05/2011
3Contracture
06/2015 - 01/2003
2Aortic Aneurysm (Aneurysm, Aortic)
04/2022 - 01/2022
2Aortic Dissection
01/2022 - 10/2013
2Hypertension (High Blood Pressure)
01/2022 - 01/2017
2Thoracic Aortic Aneurysm
01/2021 - 10/2013
2Congenital contractural arachnodactyly
06/2015 - 12/2002
2Hypertrophy
06/2015 - 07/2010
2Emphysema
06/2011 - 03/2003
1Aortic Rupture
11/2023
1Metabolic Bone Diseases (Osteopenia)
12/2022
1Chest Pain (Chest Pains)
01/2022
1Thoracic Aorta Dissection
01/2022
1Aortic Diseases
01/2020
1Inflammation (Inflammations)
01/2020
1Cardio-Renal Syndrome
01/2020
1Fibrosis (Cirrhosis)
01/2020
1Necrosis
01/2020
1Proteinuria
01/2020
1Heart Arrest (Cardiac Arrest)
01/2020
1Pulmonary Arterial Hypertension
01/2017
1Pulmonary Hypertension
01/2017
1Obesity
01/2016
1Brachydactyly
09/2015
1Arachnodactyly
09/2015
1Joint Instability (Joint Laxity)
09/2015
1Muscular Dystrophies (Muscular Dystrophy)
06/2015
1Stiff Skin Syndrome
04/2014
1Abdominal Aortic Aneurysm
10/2013
1Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
10/2010
1recessive Cutis laxa
08/2010
1Peripheral Nervous System Diseases (PNS Diseases)
06/2010
1Osteosarcoma (Osteogenic Sarcoma)
02/2010
1Incisional Hernia
05/2008
1Hernia (Hernias)
05/2008
1Cicatrix (Scar)
05/2008
1Cutis Laxa
11/2007
1Carcinoma (Carcinomatosis)
05/2007
1Neoplasms (Cancer)
03/2005
1Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa)
03/2005
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
03/2005
1Carcinogenesis
03/2005
1Systemic Scleroderma (Systemic Sclerosis)
01/2005
1Mixed Connective Tissue Disease (MCTD)
01/2005
1Familial Primary Pulmonary Hypertension
01/2005

Drug/Important Bio-Agent (IBA)

16Fibrillin-1IBA
01/2022 - 12/2002
8FibrillinsIBA
11/2023 - 01/2005
6Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2005
5CollagenIBA
11/2023 - 03/2005
5Fibrillin-2IBA
01/2022 - 12/2002
2Transforming Growth Factors (Transforming Growth Factor)IBA
01/2020 - 01/2017
2Transforming Growth Factor beta (TGF-beta)IBA
08/2010 - 03/2003
2Laminin (Merosin)IBA
05/2007 - 03/2005
1Extracellular Matrix ProteinsIBA
11/2023
1SmokeIBA
04/2022
11,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA
01/2021
1salicylhydroxamic acid (SHAM)IBA
01/2020
1Pancreatic Elastase (Elastase)IBA
01/2017
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
01/2017
1LipidsIBA
01/2016
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
06/2015
1Myosins (Myosin)IBA
06/2015
1Biomarkers (Surrogate Marker)IBA
10/2013
1Peptide Hydrolases (Proteases)FDA Link
06/2011
1Metalloproteases (Metalloproteinases)IBA
05/2011
1perlecanIBA
07/2010
1MyostatinIBA
07/2010
1Conditioned Culture MediaIBA
02/2010
1Protein Isoforms (Isoforms)IBA
02/2010
1Glycoproteins (Glycoprotein)IBA
05/2007
1nidogen (entactin)IBA
05/2007
1laminin alpha5IBA
05/2007
1Angiogenic ProteinsIBA
03/2006
1Cysteine (L-Cysteine)FDA Link
03/2006
1Plasminogen Activators (Plasminogen Activator)IBA
03/2006
1activin AIBA
03/2006
1Fibronectins (Fibronectin)IBA
03/2005
1Collagen Type VIIIBA
03/2005
1AutoantibodiesIBA
01/2005
1Recombinant ProteinsIBA
01/2005
1Peptides (Polypeptides)IBA
01/2005
1AntibodiesIBA
01/2005

Therapy/Procedure

1Cardiopulmonary Resuscitation (CPR)
01/2020
1Laparotomy
05/2008